Lewisville is a town in Forsyth County, North Carolina, United States. The population was 12,639 at the 2010 census, up from 8,826 at the 2000 census. It is a Piedmont Triad community. Lewisville is located in western Forsyth County at 36553N802458W / 36.09806N 80.41611W / 36.09806; -80.41611 (36.098087, -80.416030).U.S. Route 421, a four-lane freeway, passes through the southern part of the town, with access from Exits 242 and 244. Via US 421, downtown Winston-Salem is 11 miles (18km) to the east, and Wilkesboro is 44 miles (71km) to the west.